A unifying perspective

نویسنده

  • Laura Manuelidis
چکیده

The purpose of this perspective is to communicate several fundamental biologic features of TSE infections that may not be apparent to scientists who do not isolate and characterize infectious particles, or analyze different TSE agent-strains. At high multiplicity, TSE agents can induce pathological misfolding of host PrP into PrP-res amyloid. However, infection is not required for this conversion, and genetic host PrP coding mutations are sufficient to cause PrP amyloid plaques with no infectivity. “Prion” amyloid states in yeast and bacteria that lack the infectious characteristics

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تاریخ انتشار 2013